"Gain-of-function" research is the modification of naturally occurring viruses in order to make them more deadly and/or more contagious, especially in humans.
Safety concerns lead to the banning of "Gain-of-function" research on coronaviruses in the US in 2014, but it "came roaring back under Trump and Fauci" in 2017. Marc Lipsitch commented that this sort of research had “done almost nothing to improve our preparedness for pandemics, yet... risked creating an accidental pandemic.”
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