Difference between revisions of "Creutzfeldt-Jakob disease"

From Wikispooks
Jump to navigation Jump to search
(mention of vaccines)
(move section to Prion diseases)
Line 8: Line 8:
 
'''Creutzfeldt–Jakob disease''' ('''CJD'''), also known as '''subacute spongiform encephalopathy''' or '''neurocognitive disorder due to prion disease''', is a fatal [[neurodegeneration|degenerative]] [[brain disorder]].<ref name=NIH2003/><ref name=CDC2015Main>https://www.cdc.gov/prions/cjd/index.html</ref> Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances.<ref name=NIH2003/> Later symptoms include [[dementia]], involuntary movements, blindness, weakness, and [[coma]].<ref name=NIH2003/> About 70% of people die within a year of diagnosis.<ref name=NIH2003/>  
 
'''Creutzfeldt–Jakob disease''' ('''CJD'''), also known as '''subacute spongiform encephalopathy''' or '''neurocognitive disorder due to prion disease''', is a fatal [[neurodegeneration|degenerative]] [[brain disorder]].<ref name=NIH2003/><ref name=CDC2015Main>https://www.cdc.gov/prions/cjd/index.html</ref> Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances.<ref name=NIH2003/> Later symptoms include [[dementia]], involuntary movements, blindness, weakness, and [[coma]].<ref name=NIH2003/> About 70% of people die within a year of diagnosis.<ref name=NIH2003/>  
  
−
<!-- Cause and diagnosis -->
 
 
CJD is caused by a type of abnormal protein known as a [[prion]].<ref name=CDC2019>https://www.cdc.gov/prions/cjd/index.html |website=www.cdc.gov</ref> Infectious prions are [[protein folding|misfolded]] proteins that can cause normally folded proteins to also become misfolded.<ref name=NIH2003/> About 85% of cases of CJD occur for unknown reasons, while about 7.5% of cases are [[heredity|inherited from a person's parents]] in an [[autosomal dominant]] manner.<ref name=NIH2003/> Exposure to brain or spinal tissue from an infected person may also result in spread.<ref name=NIH2003/> There is no evidence that sporadic CJD can spread between people via normal contact or [[blood transfusions]], although this is possible in [[variant Creutzfeldt–Jakob disease]].<ref>https://www.transfusionguidelines.org/transfusion-handbook/5-adverse-effects-of-transfusion/5-4-variant-creutzfeldt-jakob-disease-vcjd</ref> Diagnosis involves ruling out other potential causes.<ref name=NIH2003/> An [[electroencephalogram]], [[Lumbar puncture|spinal tap]], or [[magnetic resonance imaging]] may support the diagnosis.<ref name=NIH2003/>
 
CJD is caused by a type of abnormal protein known as a [[prion]].<ref name=CDC2019>https://www.cdc.gov/prions/cjd/index.html |website=www.cdc.gov</ref> Infectious prions are [[protein folding|misfolded]] proteins that can cause normally folded proteins to also become misfolded.<ref name=NIH2003/> About 85% of cases of CJD occur for unknown reasons, while about 7.5% of cases are [[heredity|inherited from a person's parents]] in an [[autosomal dominant]] manner.<ref name=NIH2003/> Exposure to brain or spinal tissue from an infected person may also result in spread.<ref name=NIH2003/> There is no evidence that sporadic CJD can spread between people via normal contact or [[blood transfusions]], although this is possible in [[variant Creutzfeldt–Jakob disease]].<ref>https://www.transfusionguidelines.org/transfusion-handbook/5-adverse-effects-of-transfusion/5-4-variant-creutzfeldt-jakob-disease-vcjd</ref> Diagnosis involves ruling out other potential causes.<ref name=NIH2003/> An [[electroencephalogram]], [[Lumbar puncture|spinal tap]], or [[magnetic resonance imaging]] may support the diagnosis.<ref name=NIH2003/>
  
 
There is no specific treatment for CJD.<ref name=NIH2003>https://web.archive.org/web/20170704234755/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Creutzfeldt-Jakob-Disease-Fact-Sheet</ref> [[Opioids]] may be used to help with pain, while [[clonazepam]] or [[sodium valproate]] may help with involuntary movements.<ref name=NIH2003/> CJD affects about one per million people per year.<ref name=NIH2003/> Onset is typically around 60 years of age.<ref name=NIH2003/> The condition was first described in 1920.<ref name=NIH2003/> It is classified as a type of [[transmissible spongiform encephalopathy]].<ref>https://web.archive.org/web/20170808104028/https://www.cdc.gov/prions/cjd/about.html</ref> Inherited CJD accounts for about 10% of prion disease cases.<ref name=Man2015>https://doi.org/10.3171%2F2015.8.FOCUS15328</ref> Sporadic CJD is different from [[bovine spongiform encephalopathy]] (mad cow disease) and [[variant Creutzfeldt–Jakob disease]] (vCJD).<ref name=CDC2015Ind>https://web.archive.org/web/20170718154357/https://www.cdc.gov/prions/cjd/index.html|a</ref>
 
There is no specific treatment for CJD.<ref name=NIH2003>https://web.archive.org/web/20170704234755/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Creutzfeldt-Jakob-Disease-Fact-Sheet</ref> [[Opioids]] may be used to help with pain, while [[clonazepam]] or [[sodium valproate]] may help with involuntary movements.<ref name=NIH2003/> CJD affects about one per million people per year.<ref name=NIH2003/> Onset is typically around 60 years of age.<ref name=NIH2003/> The condition was first described in 1920.<ref name=NIH2003/> It is classified as a type of [[transmissible spongiform encephalopathy]].<ref>https://web.archive.org/web/20170808104028/https://www.cdc.gov/prions/cjd/about.html</ref> Inherited CJD accounts for about 10% of prion disease cases.<ref name=Man2015>https://doi.org/10.3171%2F2015.8.FOCUS15328</ref> Sporadic CJD is different from [[bovine spongiform encephalopathy]] (mad cow disease) and [[variant Creutzfeldt–Jakob disease]] (vCJD).<ref name=CDC2015Ind>https://web.archive.org/web/20170718154357/https://www.cdc.gov/prions/cjd/index.html|a</ref>
  
−
==COVID-19 vaccine==
 
−
There have been reported incidences of people dying of this disease in connection with the [[COVID-vaccines]]. Neurological disorders are one of the main observed effects of the [[RNA vaccines]]. Immunologist [[J. Bart Classen]] published a paper in February 2021 outlining the potential for messenger RNA (mRNA) COVID vaccines to trigger development of prion diseases. These include [[Alzheimer’s]], [[Parkinson’s]], [[amyotrophic lateral sclerosis]] (ALS), [[multiple system atrophy]] (MSA) and others.<ref>https://childrenshealthdefense.org/defender/scientist-warning-covid-vaccines-parkinson-neurodegenerative-disorders/</ref>
 
−
 
−
In a strange coincidence, [[AstraZeneca]] senior vaccine researcher [[José Baselga]] was stated to have died of CJD.
 
−
 
−
Cheryl Cohen, a "healthy 64-year-old woman from [[Florida]]" died three months after her second dose of [[Pfizer–BioNTech COVID-19 vaccine|Pfizer’s COVID vaccine]]. According to her daughter, Gianni, she received the first dose of Pfizer on April 5, and her second dose on April 25. On May 6, Cheryl experienced her first episode indicating “something was neurologically wrong.” At first doctors couldn’t find anything medically wrong with Cheryl other than a slightly elevated white blood cell count But then MRI imaging of the brain showed evidence of prion disease, and on July 12 a second lumbar puncture came back positive for CJD. No autopsy was performed.<ref>https://childrenshealthdefense.org/defender/cheryl-cohen-dies-rare-brain-disease-second-dose-pfizer-covid-shot/?itm_term=home</reF>
 
  
 
{{SMWDocs}}
 
{{SMWDocs}}

Revision as of 01:14, 17 December 2021

Concept.png Creutzfeldt-Jakob disease 
(disease)Rdf-entity.pngRdf-icon.png
Practneurol-2016-001571f02.jpg
Magnetic resonance image of sporadic CJD
A fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. Later symptoms include dementia, involuntary movements, blindness, weakness, and coma. About 70% of people die within a year of diagnosis.

Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is a fatal degenerative brain disorder.[1][2] Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances.[1] Later symptoms include dementia, involuntary movements, blindness, weakness, and coma.[1] About 70% of people die within a year of diagnosis.[1]

CJD is caused by a type of abnormal protein known as a prion.[3] Infectious prions are misfolded proteins that can cause normally folded proteins to also become misfolded.[1] About 85% of cases of CJD occur for unknown reasons, while about 7.5% of cases are inherited from a person's parents in an autosomal dominant manner.[1] Exposure to brain or spinal tissue from an infected person may also result in spread.[1] There is no evidence that sporadic CJD can spread between people via normal contact or blood transfusions, although this is possible in variant Creutzfeldt–Jakob disease.[4] Diagnosis involves ruling out other potential causes.[1] An electroencephalogram, spinal tap, or magnetic resonance imaging may support the diagnosis.[1]

There is no specific treatment for CJD.[1] Opioids may be used to help with pain, while clonazepam or sodium valproate may help with involuntary movements.[1] CJD affects about one per million people per year.[1] Onset is typically around 60 years of age.[1] The condition was first described in 1920.[1] It is classified as a type of transmissible spongiform encephalopathy.[5] Inherited CJD accounts for about 10% of prion disease cases.[6] Sporadic CJD is different from bovine spongiform encephalopathy (mad cow disease) and variant Creutzfeldt–Jakob disease (vCJD).[7]


 

A Creutzfeldt-Jakob disease victim on Wikispooks

TitleDescription
José BaselgaChief cancer researcher at AstraZeneca dies at 61 of Creutzfeldt-Jakob disease, possibly an effect of the Covid jab.
Many thanks to our Patrons who cover ~2/3 of our hosting bill. Please join them if you can.


References

  1. ↑ a b c d e f g h i j k l m n https://web.archive.org/web/20170704234755/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Creutzfeldt-Jakob-Disease-Fact-Sheet
  2. ↑ https://www.cdc.gov/prions/cjd/index.html
  3. ↑ https://www.cdc.gov/prions/cjd/index.html |website=www.cdc.gov
  4. ↑ https://www.transfusionguidelines.org/transfusion-handbook/5-adverse-effects-of-transfusion/5-4-variant-creutzfeldt-jakob-disease-vcjd
  5. ↑ https://web.archive.org/web/20170808104028/https://www.cdc.gov/prions/cjd/about.html
  6. ↑ https://doi.org/10.3171%2F2015.8.FOCUS15328
  7. ↑ https://web.archive.org/web/20170718154357/https://www.cdc.gov/prions/cjd/index.html%7Ca
Wikipedia.png This page imported content from Wikipedia on 31.08.2021.
Wikipedia is not affiliated with Wikispooks.   Original page source here
Retrieved from "https://wikispooks.com/w/index.php?title=Creutzfeldt-Jakob_disease&oldid=232057"